Dominic D’Agostino, Ph.D., has maintained involvement in a vast array of professional, academic and personal endeavors. As an Associate Professor with tenure at the University of South Florida, Dom teaches students of the Morsani College of Medicine and the Department of Molecular Pharmacology and Physiology, with a focus on such topics as neuropharmacology, medical biochemistry, physiology, neuroscience, and neuropharmacology.
He is also a Research Scientist at the Institute for Human and Machine Cognition (IHMC) to assist with their efforts towards optimizing the safety, health and resilience of the warfighter and astronaut.
His laboratory develops and tests metabolic-based strategies for targeting CNS oxygen toxicity (seizures), epilepsy, neurodegenerative diseases, and cancer. His current project is to identify cellular mechanisms of seizures from CNS oxygen toxicity and to develop mitigation strategies against it. His efforts have focused specifically on measuring brain EEG, neuronal excitability, reactive oxygen species (ROS) production and biomarkers of oxidative stress. The main focus of his lab over the last 10 years has been understanding the anticonvulsant and neuroprotective mechanism of the ketogenic diet and ketone metabolite supplementation. The shift in brain metabolism (from glucose to ketones) reduces neuronal hyperexcitability, oxidative stress and enhances brain energy metabolism.
Other areas of interest include researching drugs that target cancer-specific metabolic pathways. He was a research investigator and crew member on NASA’s Extreme Environment Mission Operation (NEEMO 22) and has a personal interest in environmental medicine and methods to enhance safety and physiological resilience in extreme environments. His research is supported by the Office of Naval Research (ONR), Department of Defense (DoD), private organizations and foundations.
[3:44] Making two different diets work at home
[7:14] Life underwater for 10 days
[20:01] APOE4 and the Ketogenic diet’s effects on Alzheimer’s disease
[27:37] Effects of removing dairy and saturated fat on biomarkers
[33:21] The ketogenic diet and atherosclerosis
[37:40] How to build muscle in ketosis
[41:27] Taking a year off from weightlifting
[47:40] How to lose the benefits of intermittent fasting
[54:10] Dr. Dom’s opinion on one meal a day
[56:16] Should you schedule cheat meals?
[1:06:00] The importance of micronutrients
[1:08:05] The best keto snacks
[1:13:40] Adherence and ketosis
One of my favorite tools for cognitive enhancement, especially after long plan rides, is Blue Cannatine. The delivery mechanism is unique (buccle troche). It is especially effective for me on improving short-term memory, focus, and verbal fluency. It’s the closest thing that I found to NZT and I think you guys should try it out. Enter the code BOOMER for 10% off your purchase. Full disclosure: I am involved with the company (I like the product that much).View Company
I’ve been fascinated by blood flow restriction training for a very long time. And the guys at Bstrong did some really cool innovations with their technology. I use it just about every day, high reps, low number of sets, a few exercises. And in 20 minutes I have a fantastic workout, which I know is triggering an anabolic response and who doesn’t like that. So if you want to get your Bstrong blood flow restriction device, head on over to bstrong.training and enter the code BOOMER for 10% off.View Company