Nutrition

Exploring the Next Frontier: a Deep Dive Into Peptides with Jean Francois Tremblay

Boomer Anderson
December 25, 2019
109
 MIN
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Peptides and performance enhancing drugs are an often-misunderstood topic. Jean-Francois Tremblay discusses the differences between SARMs and Peptides, the repairing peptides (BPC157), growth hormone, and many others.


Who is Jean-Francois Tremblay?


Jean-François Tremblay studied Exercise Physiology, Biochemistry, and Pharmacy.


He is now, a student and researcher at UQAM. He has been researching (in theory and in practice) peptides and SARMS since the 90s and published multiple studies on this matter, based on his own research. He had been studying the theoretical basis on what peptides are and their practical applications in sports performance, anti-aging, and health in general.


His most recent work has been based on the premisses that the loss of muscle function (loss of muscle mass (sarcopenia), muscle strength (dynapenia) and muscle quality (muscle strength / mass)) begins at the age of 30 and continues exponentially with age in all the individuals.


The mechanisms responsible for the loss of muscle function in the elderly are not yet well known, but probably involve various systems (physiological and neuromuscular) and this, in particular, is the main object of study of the CanLab laboratory. Jean Francois Tremblay is a biochemist that has dealt with peptide, SARMS, both in theory and in practice since the early 1990s.



Highlights


[3:23] What are peptides

[8:18] The various effects that peptides can provide for people

[13:32] The FDA and a potential for Peptide Bans.

[29:00] Cycling Peptides

[33:54] Applications for BPC 157

[47:00] The effects of Melanotan II

[57:11] Discussing growth hormone

[1:13:17] Dosing

[1:21:50] Downsides

[1:23:41] Sourcing


Resources

BPC 157 and Blood Vessels

Melanocortin receptor agonists, penile erection, and sexual motivation: human studies with Melanotan II

Ipamorelin, the first selective growth hormone secretagogue

How to Live Forever with Dr. Aubrey de Grey

Oura Ring

Fitbit Alta

Life Extension: A Practical Scientific Approach

Episode Transcript

Boomer Anderson 0:06
Welcome to decoding superhuman, this show is a deep dive into obsessions with performance and how to improve the human experience. Twice a week, I explore the latest science, technology and tactics with experts in various fields of human optimization. I’m your host, Boomer Anderson. Enjoy the journey

superhumans one of the most requested topics for this show is peptides when combing the universe of experts And people who have both theory but also practice with peptides, one name continues to come up. And that is Jean Francois Tremblay. He is a biochemist. He studied pharmacology, and he has worked in exercise physiology. Jean Francois has dealt with peptides arms, both in theory and in practice since the early 1990s. So I was absolutely thrilled when he accepted the invite to come on the show. In fact, when we were emailing, I said please a lot 90 minutes to talk about this topic, and he told me 90 minutes would really just scratch the surface and leave it to the expert to be absolutely correct. Today, we just scratched the surface on peptides going into things like what are the differences between Sarms and peptides? BPC 157 we get into Tessa and ipamorelin talk about cjC and so many others. But again, we are just scratching the surface. I’m extremely grateful for john Francoise time. So let’s pass it over that conversation. The show notes for this one, you’re going to want to check those out our decodingsuperhuman.com/peptides.

Jean Francois, thank you so much for taking the time.

Jean Francois Tremblay 2:22
Hey, no thanks to you.

Boomer Anderson 2:25
So today, and one of my favorite things about hosting the podcast is when I want to go deep on a topic and learn as much as possible. As a person. One of the things I get to do is reach out to experts in these fields. And so today we’re going to be talking about peptides, which I’ve done a little Guinea pigging on this, but I’m looking forward to this conversation very much.

Jean Francois Tremblay 2:51
Okay, great. So,

Boomer Anderson 2:52
let’s get started. So what I want to do before we go into the weeds, so to speak, is Just lay the foundations for people because there may be some people who are relatively new to this field listening to this, but how would you explain a peptide to anyone who’s listening right now?

Jean Francois Tremblay 3:15
Okay.

Well, basically, peptide is

a smaller protein. Basically, it’s a chain of amino acid. And what makes it different from protein is that it’s the number of amino acids usually adds maybe up to 50, 60 amino acids. can be, listen, growth hormone could be classified as a peptide because it’s a chain of 191 amino acid but that’s kind of borderline it’s almost a protein because it’s folded. itself. So it’s not a linear chain, but basically it’s a chain of amino acids on the man. If you hook up many different peptides, that becomes a protein. So that’s the breakdown protein that died. And if you break it down more, you get amino acids.

Boomer Anderson 4:21
Okay, so the folding is that the differentiating factor or is it just,

Jean Francois Tremblay 4:27
well, that’s important, actually, for some peptides protein like growth hormone, because it’s a long, it’s not only a linear chain of 191 amino acids, but then the chain folds on itself a few times, if I’m not mistaken, it’s three times. So that gives kind of a 3d dimension to the molecule. And it needs to be there for activity for the receptor. Through recognize it. So

Boomer Anderson 5:02
yeah, amazing. So one of the other areas and I just want to differentiate between the two topics before we go deep here that comes up when we’re discussing things like performance enhancement is sarms. Oh, yeah. Do you mind just differentiating between peptides and sarms?

Jean Francois Tremblay 5:22
Okay, well, peptides are naturally 99 point something percent, we produce them in the body already. So all those peptides You see, advertise or what we’ll talk about, we produce them naturally in the body or fractions of naturally occurring but sites as sarms, they’re totally synthetic. Basically, they’re very unrelated to steroids. In terms of structures, in terms of effect, they have a lot of similarity. But actually, if that’s, you know, I’ve been wondering for a long time because you look at the molecule of a song, and it looks like nothing we know doesn’t look like testosterone or dairy vade at all, but it turns out that and that’s all back in the 90s. That Well, the drug itself is older that there was a anti androgen and there are take Molly molecules and it will be used to block the receptors to testosterone, you know, for some disease, you need to block that activity. So some guy in his lab, one day thought it says a, what if because those molecule as a higher affinity for the receptors, then testosterone. So one guy thought you say, since they have such a high affinity, what if we could modify it? So instead of, because what it was doing it would bind to the receptor, but within start the cascade of events, you would just blood your receptor. So I thought, hey, what if it would bind and started anabolic cascade and they started to tweak with that drug, that molecule and sounds horrible. So that’s how the game they they were born actually from NC androgen to being modified to become not transgenic, but more anabolic. So very few people know that.

Boomer Anderson 7:50
It’s fascinating to see that we can develop something so powerful by almost looking at the exact opposite effect. Again before just setting foundations for people, peptides can have a variety of effects right? And these can be so wide ranging, do you mind just touching a little bit in terms of what are the various effects that peptides can can provide for people?

Jean Francois Tremblay 8:18
Well, they have pretty much any effect you know, we there has been more than 7000 peptides identified already in the body. We don’t know all what they do. But if you look at research now what happened is almost every week there is a new article coming out and it’s not an article pointing out a new peptide they found they knew it existed, but just some theme they say okay, let’s look now this one, what does it do so the the identity If I the function of those peptides, so and they have a lot like over 7000 to look at, so, but it’s going very very fast and they’re everywhere in the body and it can go from repairing to modulating hormones to aesthetic scan, your pretty much somewhere every step of the metabolomic pathways. It’s probably that trades growing so big. Now pharmaceutical company jumped in the, the train because they saw the potential they saw the booming of it. So of course they want their bigger piece of advice, of course.

and the more and the brother uptake I said the next the new fronteer in medicine. If it goes as it should go, probably within 10 years, you will see a doctor and it would be rare that you don’t come out with a prescription for some peptides.

Boomer Anderson 10:19
So one of my understandings of peptides is because they’re not patentable, you know, a lot of these pharmaceutical companies are not really investing the dollars. They are now they are now Okay, so what’s changed all the way.

Jean Francois Tremblay 10:38
If you look at the newer patents, you will read, peptides stayed, okay method of synthesis, they pattern the method of synthesis, but that’s easy to tweak so you don’t break the pattern. But okay, method of synthesis and its applications. So they don’t pattern the peptide. The patent the application of so and then they would list all the disease or condition that this peptide can work on. So, for example, time is in alpha one immune system peptide that it will they know for sure it but be it, but I just be it but I did see cancer that that they will list everything. So now, I then they sell it in pharmacies. So if another company wants to sell peptides in pharmacy, they have to find another application, because the doctor or the US this will have the obligation if it’s for it, but I see it will have the obligation to give the patient that one from that company that has the patent for that application. So now they got that so they’re starting to enter the market.

Boomer Anderson 11:58
Yeah, pardon my French Chair, but that seems like a crock of shit way to file a patent. You’re just saying like, hey, this could work to this.

Jean Francois Tremblay 12:07
Well, you’re surprised.

Boomer Anderson 12:09
Yeah, I guess I shouldn’t be right.

But it’s just, it’s unfortunate because you have this very, as you say, natural compounds in these bodies that could lead to amazing effects. And we’re going to now corner the market with some sort of drug company

Jean Francois Tremblay 12:27
and and the of course, there is a very strong relationship between the FDA and the US and pharmaceutical companies. So now FDA is slowly starting to probably will be able to stop compounding pharmacies to compound peptides because in the states that’s possible. So they’re starting to kind of crack down on that and probably Next step will be to crack down on internet sales of peptides as research chemicals. So

Boomer Anderson 13:08
this is interesting because this happened was sarms. Right?

Jean Francois Tremblay 13:13
It’s kind of happening.

Boomer Anderson 13:15
Yeah. And now it’s so I’ve heard about this factor with the FDA basically making banning peptide formulations and compound pharmacies. And you say, How How far do you think we are from that? Well,

Jean Francois Tremblay 13:32
keep in mind, after all their government people, you know, they’re not that fast. They’re, basically they’re paid by the hour. So, but yet, not so far. With peptides. It’s hard to tell it depends. Once they get the pressure for pharmaceutical companies, Go fast, because I know there is a lot of lobbying money behind. So that’s a big incentive. It’s hard to tell. And that’s for the US, doesn’t mean that will happen worldwide. In Canada, we have a tendency to follow what’s happening in the US in terms of pharmaceutical laws. Not all the time, but most, but were like, just to give you an idea, usually work two, three years behind. So that happens in the US, maybe two, three years after and worldwide, depending on the countries that may happen and some may not happen and others that’s yet to see. Gotcha. But eventually, it’s hard to give a timeframe. medium term, it

Boomer Anderson 14:50
will happen. Interesting. Jean Francois, how did you get into this field because I know a few years ago, it was very You know, it was kind of heard of on the Reddit threads on the internet. It wasn’t it wasn’t really a mainstream,

Jean Francois Tremblay 15:06
there was a huge underground culture. And, okay, I mentioned that in other podcasts too, but if you will back the actual first biohackers that that name didn’t exist back then. Yeah, we’re bodybuilders even from the 60s 70s. You know, they are the first who started to use steroids. But it went further than that. They were always looking at what could they use supplement drug wise, whatever, not only to improve, to improve every aspect of their endeavor know get bigger. So it went from further than just steroids they would look into Okay, what can I use to improve my focus during training? and bang? They weren’t to no tropics or because if they were using a lot of anabolic steroids that hard time to sleep or develop anxiety so buying their into sleeping stuff and you know they were not only steroids people that thing oh yeah steroids now this week with and I’m from, I was not a bodybuilder but back in the 80s and 90s I wasn’t that were and basically, they were way in advance and peptides you know, the the repairing peptides if they would get an injury. That famous tanning peptide of which I heard back in the 90s you know, reading in the French magazine. That’s that was my first introduction to peptides. So basically that that comes a long way back, but because that’s the subculture, it would stays within that subculture and not go out so much. So it was kind of the little secret of in the sport war, you know, and, you know, you would see an athlete’s a professional athlete to earn that he got injured for whatever and you say all that said, it’s finished and bang, three weeks after his back playing, you say, Well, what happened? Yeah, steroids don’t do that. You know, other things, too. So it has been there for a long time. But within as you said, it would pop out on Reddit on the on those forums. It has been there and on time. Yeah, I know. It’s getting mainstream almost basically. So

Boomer Anderson 18:00
And this fascinates me because I was a loose participant in the bodybuilding world in the early 2000s. And it when you started getting really into that, I first I think that people need to realize that the concept of performance enhancing drugs is no longer necessarily a bad thing. It’s not some guy mixing testosterone and his bath in China. There’s better ways that we’re doing that. But what we’re talking about here, some of these early adopters were kind of the controversies in Major League Baseball, right?

Jean Francois Tremblay 18:36
For example, yeah. What’s his name? baseball coach, oh, the baseball and he started and, and, and those people there, they’re crazy and they kind of in a good way, is the one who discovered kind of that or some doctor working with him, you know, intranasal insulin. Who would of that, you know, Okay, let’s try it up for those. And bags, they got an amazing effect. And I’m telling you, because bodybuilders they don’t mind or high level professional athletes, they don’t mind going to the extremes. And if it may work, they’re gonna try it. And if they have no clue Well, there’s only one way to find out and they’ll try it. And I’ve done it too with a few things. It served me well. So but so far, but, you know, that’s and that size advance, actually, you know, science. It’s rare that they actually discover something. I would say that 90% of the time, scientific research is is more historical research. You know, they take something that oh, you know, people are, you know, it’s being used as a time. Let’s look at why it works, and then they go into that research, but a lot of time, it’s not it’s done already. And a good friend of mine, Charles polycon, used to say, you know, practitioners are always ahead of the curve. And you wouldn’t mention a study that came out in 2005, about one training training method. And it was the title was, I don’t remember that technique. But anyway,

I could send you the study, if you want please do later.

In 2005, is a new approach to strength training or something. And when he saw that, you say, well, I’ve been doing that for 30 years. Talk to his coach, that one will tell them that method and they went back like in the 40s, you know, when it was used So he said and not this guy decided to do a study about it found it worked and published. But Charles was a practitioner. So he said, Look, if I had waited for that study to come out of the Olympics will pass by. So it’s the same in that field, you know, and that’s why now that Bio hacking word, that’s amazing, you know, it’s an equal one most of the time. But it’s better than n equals zero when at least you have good clues on things that they make. That’s why part of what I do it because I do have a company that make peptides but I try to together close relationship with my clients. I give consultations online and all that and because I learned a lot from the feedbacks of people using them, and the kilee not it’s like hundreds and hundreds I get feedback from great Oh, okay, you know, I tweak with that then see okay, that didn’t work that work. Yeah, it’s it’s fascinating what’s happening. And I’m not publishing anything. So if you’re waiting for publication of what is being done right now, well, it’s not gonna happen on my side. So don’t you know that that’s one thing the trend we have today of research base. It’s a good thing up to a point but we went to the other extreme, you know, the pendulum and that makes a lot of people discard the clinician, that’s the word I was looking for.

When you go see a doctor, a good one, what’s the first thing is going to do? is going to ask you questions is not going to answer it. is good. Within 10, 15 minutes, he has a pretty good idea of what’s wrong with you. But because we’re so science base now, then he has the obligation to send you to do a bunch of tests, which is very costly to support whether you knew already, most of the time there is a reason because sometimes we make mistake if you will have done that, that then you know, but to give you an idea that there is a balance of things. So now they’re at the extreme that it has to be backed up by a bunch of tests. Eventually, a whole bit will reach medium point where, you know, when I talk about clinical experience from people working with that, you know, you think some people have worked in the field for 10-20-30 years, and they’re pretty good that they know what’s happening even if it’s not published. So if again, if you wait for publication, you may wait a long, long time. So there’s so many questions. I

Boomer Anderson 24:16
can go on the back. Yes, because I would love your opinions on things like Myostatin knockouts and all that stuff. Yeah. But when we’re looking at the bodybuilding world, specifically is the bodybuilding world has been early adopters to some of these compounds. Many people are going to say the longevity of the bodybuilding world and some of the downsides that happened to these guys later on in life. Okay, I would love to hear your opinion on Yeah.

Jean Francois Tremblay 24:45
They’re too big. That’s, you know, we talked now that obesity is is is bad and it’s short turn your life but me I believe it’s not obesity, per se, it’s the overweight and that’s kind of what you see with bodybuilders and you know there is an age for everything. So if you weighed 260 pounds, when you’re 30 your body can take it if you are a bodybuilder and don’t want to give that up and do everything you can to still wait to 40 to 50 when you’re 55 when you’re 60 now, you know your organs, your heart, everything No That’s too much. And and that’s being overweight, too. So look at in Japan, where they have the highest longevity, but you look at sumo wrestlers, and they you know they’re big fat, but they’re very muscular, and they’re healthy. Fish rice, you know a lot of it but basically it’s a very healthy diet. Their life expectancy is 60 to 65 years old. And that’s all related, I believe to their overweight and you will see that in the bodybuilding world. You have those guys they don’t want to give up for whatever reason, and those are the ones who don’t live so long. You look at other ones. Yeah, look at Arnold Schwarzenegger. The part where he became vegetarian but just you know, the guy is is healthy but you know, he doesn’t wait the 200 and something pounds you know, they realize, you know, Ben pakulski is a good friend of mine and is allotted to longevity now, and his problem is trying to lose weight, but the He has a hard time you know, his muscular mass is there. But he wants to lose some of it, he realized that now you cannot carry that much weight. And it comes down to that carrying too much weight doesn’t matter if it’s muscle or fat, too much weight is too much weight.

Boomer Anderson 27:17
Well said Well said. So let’s transition now back into peptides. And before because I have to throw this disclaimer out there, you know, anything that we say here is not medical advice, you know, people No, no, no, no. Yeah, we’re just sharing information. Please do do your own research. But it just general things with peptides. I would love to just hear your thoughts about a lot of these are injectables, right? And many people are listening most of them. Yeah. Almost all of them actually. And most of those are subcutaneous, right. Is there any dangers and injections You’re injecting yourself.

Jean Francois Tremblay 28:01
And the injection even given by the best of doctors, there is always, always always risk of infection if you don’t do it, right. Otherwise, no, because it’s suck, you know, you know that air bubble and the syringe that’s when you do intravenous, you know, otherwise we’ll have to worry about that. So no, there is a risk of doing it. diabetic people, they do it for decades, ooh, three, four times a day. Nothing happened. You know, it’s it’s, it’s amazing, the safe and most people you know, it’s the first time and they say, Oh, that’s it, you know, and it’s really nothing basic. The fear is much bigger than the actual

Boomer Anderson 29:00
Okay. So, is there a broad not prescription here but just recommendation around cycling? Are all peptides needed to be cycled or are certain ones can you run them forever? Well

Jean Francois Tremblay 29:16
the concept of cycling I drink come from comes from the bodybuilding world they would cycle and abolics because it would take a lot of it and you know to give a break because they can be harsh on the organs on your skin on your own production. So you know, they would cycle to kind of decrease long term the side effects of high dosages. So the concept transpired to the biohacking work for for example, you know, you’ll hear many times all when you makes your peptides, you know, because they come and bother and you have to add water No, you have to be careful. Shake it. Well, that comes from bodybuilders using growth hormones back in the 90s. And as I told you growth hormone is folded three times and that fold is all held by weak bonds. So yeah, if you shake it too much, you’re gonna break those bound those bounds break the tree the aspect of the molecule and then it’s not gonna work. So it’s it transpired two other pet dies. Oh, but no, no, the they’re much more stable than growth hormone. But they assume that if that was true for growth hormone, it’s true for all other peptides. When it’s not most of them, you know, you could shake it. Listen, we make the dates at the last last step of Just before live finalization we put them in other call it well you have seen when you go buy paint and you can ask them to shake or gal

Boomer Anderson 31:13
yeah exactly

Jean Francois Tremblay 31:14
there is little apparatus like that to be sure it’s all dissolved so we put but it’s a micro ultra sound vibrations and all all all the peptides in liquid go through that to ensure 100% dissolution so if they were to be breakdown broke down they would be broken down right there because it shakes like a lot and no and then we retest after you know and purity the rains it doesn’t affect their very very stable

Boomer Anderson 31:52
basically so me dropping that bottle of BPC 157 is probably not a big issue.

Jean Francois Tremblay 32:00
Not at all. Okay. And and and other people, they think that that’s funny they say yeah, but, you know, if I keep it too long at room temperature, will it turn bad? Well, no, you know, it’s not milk, it doesn’t turn that one day, it’s all good. And the next day, it’s no good. Over time, you may have little degradation when it’s in liquid, some faster, a few, you have to be very careful, it’s very fast, but most of them it’s very long. And that degradation, let’s say, BBC 157, could be you as a 990 9.3% that died. And maybe after two weeks, it’s going to be down to 99.2 or 99.1. You know, a little will be gone but the ball will be there. It’s going to be as effective. So be on this Stand it’s a lot of misconception about degradation and effectiveness and

yeah, and most of it comes from growth hormone.

Boomer Anderson 33:13
Interesting. Let’s dive into some of these peptides if you don’t find because, you know, since I have you I have to ask whole bunch of questions. So we’ll start with the helium peptides and just kind of the one that we just mentioned. So, BPC 157, is something that I’ve guinea pigged on myself a little bit. And I’ve certainly used it or recommended it to people with with gut healing issues. What are some of the things that we can use BPC 157 for and can’t? Because it seems like it seems like a miracle miracle pill

Jean Francois Tremblay 33:54
sometimes. Yeah, when I talk about that, but I feel like you know, those snake oil sellers you know, 100 years ago, cures everything and all that. This one actually does. It’s listen it’s so broad and it’s not all published but then clinical experience mine and from other clinicians it’s almost more wrong proof peptide you know somebody wherever you have you’re not sure just a BPC and chances are it’s going to fix it. It heals everything. So far You know, I’ve seen people with prostate problems with liver problems with kidneys problem lung prob, brands, brain problems. And that’s beside what it’s mostly known for, you know, from skeletal muscular injuries. It fixes pretty much Everything it’s repairs everywhere. So pan amazingly good to fix the guts, you know, intestinal permeability, it’s it works amazingly there. So, again, the only thing that you have to as a clinician when you use peptides and more so, if you work with people who have some kind of disease or condition is that if part of that condition is some form of autoimmune condition, some people actually develop, have an auto immune response to the peptides interesting. They recognize it as a fine agent. And so, if you if the clinician suspects that some autoimmune condition You should start with very small dosages and have some Benadryl that too for a case. That’s on the bulk. It’s rare, but I truly I got aware of that not so long ago when I started to work with people who had chronic fatigue, Lyme disease and autoimmune conditions and you know, at the beginning they say no, if I take peptides, I get a knee, I say, What are you talking about? But yeah, it may happen, you don’t see it much because those condition, you don’t see them that often. But that’s, that’s the one thing you have to be careful of. So all the ways what I tell people if you never ever use peptides, the first first time maybe use a fraction of what you intended to use, and wait wait 20 minutes, half an hour. And look, if there is, if it’s a small quantity, it’s going to be more local bash, or it’s gonna be very red than that with indicates some kind of autoimmune response. And then you have to take another approach.

Boomer Anderson 37:16
So one of the things that I’ve found fascinating about peptides is the idea of dosing, because as you’ve mentioned their papers coming out time and time again, like, almost, probably by the time we’re done this interview, there’s at least a dozen other papers, right? Yeah. And dosing is always individual. How do you look at dosing? Maybe we can use BBC 157 as an example. Because are we should we be doing sort of like with psychedelics, the Shogun Method of titrating or how do you look at that? Okay.

Jean Francois Tremblay 37:51
What I found is that it’s the response is those related bluntly The more you take the more effect you will have. And I’ve seen very high dosages of peptide use that usually that most people and with no so far with no diminished return, you know, many times when you take a compound, there is one point where if you double the dose you want double the effect that’s called a diminished return and it gets kind of worse as you take more but with that tied with most of those I’ve worked with I didn’t see that diminish return yet probably they exist but that much higher dosages. There is that the other one that’s a great usually I like to work, use them both at the same time because they do pretty much the same thing but from different angle. It’s time isn’t that that for that sentence. amazingly good with hearing that died. And there is one study it was studied, where they wanted to see the toxicity of time as in beta four or Tb 500. And they gave up to 1.26 gram.

Boomer Anderson 39:22
That’s, that’s a hell of a lot of Peptide. That’s

Jean Francois Tremblay 39:26
nobody, like nobody takes that. Yeah. But they gave that to a group of people for 14 per day for 14 days in a row. And then they stop and basically they conclude the they didn’t want to go higher, but they say no, like that. no side effects. Everything is good. You know? Probably they ran out of money. So they say no, we are good with this one. High dosages no problem. That’s what’s for 14 days. Maybe like yeah Because some people they talk about long term side effects. And that’s another thing.

If you look on papers at the pathways that are used, some people may deduce that Oh yeah, that could be bad for you. But

Boomer Anderson 40:25
which pathways are we talking about here?

Jean Francois Tremblay 40:27
I don’t know the specific very general but could be a pathway that may be pro cancer for example.

Boomer Anderson 40:36
So I am tour just take for an exit

Jean Francois Tremblay 40:39
for em tour that’s another pathway or and became pathways or other intermediary biochemical pathways.

So the thing is, there is all compounds they work through different pathways. What’s important, it’s not to look at only one pathways, but it’s to look at the global effect. And again, that’s where conditions are ahead of the curve. And when I say clinicians I’m not include on the doctor MD now could be the coach who has been working with professional athletes and use those peptides for 20 years, he has a pretty good idea of what’s happening. And the point is that it has been used for a couple of decades already. Those mainstream ones know. And nobody got cancer. And let me tell you, if one person would have got a cancer from that we would know.

Boomer Anderson 41:45
It’s like the Tesla crashing right on

Jean Francois Tremblay 41:47
Yeah, it would be all over the place. And we’re talking millions of people that’s on Publish. That does show to say, but No, nobody got cancer from that or bad thing. Are you tired leg growing up? or things like that? No, no, no, it’s not happening. So back in the 80s, we had I was hearing the same thing about steroids, you know, cancer and you don’t know in 30 years. What’s going to happen were not worked 30 years after. And now, you know, besides people dying today, as we mentioned before, it’s not because of the actual steroids. It’s because of the extra weight that is kept using them. But you know, it’s not the if a guy in his 50s gets a heart attack, it’s not the actual steroids that gave him the heart attack. It’s the side effect or the effect of using it is the overweight. Maybe it’s diet combined to that. Yeah, it’s gonna get harder. Die because this artist is in no condition so that you understand what I’m saying. Right? Basically with that ties, that’s what, that’s what you see. Okay, there is always you know what, how King said, you know nature, there is no free lunch. So you may pay a price for benefits, you’re getting a peptide, but truth is for most of them. So far, I don’t know what the price is. That’s pretty much a free lunch so far.

Boomer Anderson 43:33
So just on BBC 157. Coming back to that in if you were to take it for, let’s say leaky gut or some sort of gut issue, oral versus injectable. And I guess the second caveat on the injectable is do you need to inject it in the stomach lining, or is this sub q

Jean Francois Tremblay 43:55
that’s probably no. If you take it sub Q, then you get a systemic effect. It doesn’t matter where you inject it. Some people that talk about near the injury if it’s a skeletal muscular injury, but near is not good enough, because what is near for you, if you look closely, you know, if you have an elbow injury and you do a sub q near, there’s still a bunch of tissues between the actual injury and the injection site. So your peptide will be snatched by blood circulation and welcome back to the injury. True, systemic process. It does work. Local, and I know of some doctors doing infiltrations peptides like they do with cortisone. They do with peptides, but that’s like with the ultrasounds and they go right into the injury sites interesting and you have a better effect because the peptides, they they respond to basically inflammation and other signaling factors. So if you shoot all of the peptide at the injury site, it won’t start to go around these guys, they all were there, you know, and there will concentrate there before going into circulation, so you will get a much better effect but that’s very specific to inside, right at the injury not near the end, that that doesn’t cut it, you have to be right into it.

Otherwise, it’s a systemic and you could inject in your foot for elbow problem and you would get the same results. The other approach And you still get the systemic effect is oral and BPC 157 is one of the very, very few that has. Its overly absorbed but poorly. So you have to at least in that case, double the dosage, okay. And even if it’s for a gut issue that’s a bit like when I explain, yeah, it’s inside the guts, but it’s not inside the injury. It will diffuse systematically to come back to that gut problem. So it’s not because it’s all wrong, that it’s going to work better for the guts that submit it will work great because it does work great for the gut, but the same as an injection. But that just think dosages

Boomer Anderson 47:00
I want to transition some that I haven’t actually played around with myself yet, but I’m more curious than anything. So looking at, actually, you know, that’s funny. Yeah, because we’re going to transition now into talking about arousal peptides which are Wow, we’re gonna have some fun here. So Melanotan II and some of them Melanotan II family. I would love to hear more about these because subjectively some of our mutual friends have taken it and one of the side effects that they know to are spontaneous erections, right? I would love to it could also be a positive,

Jean Francois Tremblay 47:49
is it there is kind of delay to the effect. Some it’s fast if they take a lot of it. But there is a delay that can be anything between 2 and eight hours. But yeah, it’s definitely theircompany a few years ago they wanted to market to, to compete with Viagra. You guys actually, again, clinically, I’ve seen that you get a much I’ve been told, you know, you got much better effect

and more. So it’s not only the erection because all those Viagra, Cialis, they work locally right to get better validation and everything’s work that’s all local. And I’m not trying to and it’s very vague, the PT one for one, you get the same effect with the timing. So it’s pre target that there It works in the brains in the receptors for Msh in the brain that okay, it will provoke erections, but it will increase libido and from A to Z meaning that you actually get better orgasms when when you use those compounds. What to say?

Boomer Anderson 49:34
How about Melanotan II in particular? Yeah, yeah, that’s true. I’ve seen people come back very brown because the the melanin effect,

Jean Francois Tremblay 49:45
but what because they like it too much for the other effect it turned black so

Boomer Anderson 49:51
aside from the two that we’ve mentioned any additional effects Is there a knock on effect to testosterone with Melanotan II

Jean Francois Tremblay 50:01
It may raise a bit. Lh I think, but again, you know, like people they say it’s even the cat’s a bit appetites so they will introduce it in the weight loss program. But that’s my you know, I wouldn’t count on that to lose weight you know, it’s the effect is there but its mouth. So and for most people overweight the problem often is not metabolic it’s psychological Of course. So even if you give them something to my appetite, they will overwrite that and keep eating. So now if you’re on a diet and you’re controlling it and everything is good, and then you add a compound like elanotan II, yes, sit well help to be less hungry. but not the other way around don’t use it to become less hungry and hoping to lose weight.

Boomer Anderson 51:06
Yeah yeah, I think just in general I think going for pills to lose weight is a pretty poor I or injections as a pretty

Jean Francois Tremblay 51:16
no because everybody is looking for the magic pill for everything and no we’re not there and we’re far from there. All those peptides and compounds is their tools to add to the basic exercise diet, sleep hygiene, you know all those things. You have to do it and then you add peptides to support and make things work better. Okay, it’s like no tropic. Yes, people they take them and they say Wow, it’s not working Yeah but whether you’re doing or you’re sitting in front of the TV watching TV all day, if you don’t use your brain, it’s like a muscle then it won’t grow. So first you have to give the stimulus and then the no tropic will add will make it work better. So it’s the same thing with those compounds. They do work but if you depend on them and and that’s the sad part about biohacking. I’ve been to a few biohacking conferences, and it’s amazing the number of people attending even presenters that are out of shape. A B sometimes you can see in their face, they’re not healthy, but they’re biohacking. They’re looking for that magic bill trying all kinds of combinations. It’s not gonna happen. And again, for no tropics, this say Oh, No tropics won’t make you more intelligent. At best, they will help you keep what you have. Which is amazingly good. You have to do that. But become more intelligent you know that limitless pill

Boomer Anderson 53:17
NZT everybody’s looking for that.

Jean Francois Tremblay 53:21
Because there are people looking for it, you know, in labs and everything. Eventually probably they’ll find something. But we’re not there yet. There is one molecule it’s a protein. That’s the croteau protein. Yeah, close. Oh, this is a fat this promising. You know, it showed natural increase in IQ from two to six points, I think wow, this

Boomer Anderson 53:48
is, before we go down, I do want to talk a little bit more about Melanotan II. But close though. Get close up anywhere right now. You don’t have time for that 45 minute jog. Frankly, who jobs anymore? You need something fast, efficient and leaves you wanting more. My favorite tool for this, and I love it is the Carol. She is a life changing bike that provides you all the endurance you need and to 22nd burse Yes, you heard that correct. That’s 40 seconds of Max effort, including the warm up and cool downs. You get a kick ass workout in eight minutes and 40 seconds. How? The Carroll’s resistance bike powered by artificial intelligence, which personalizes and optimizes the resistance, so you hit your maximum intensity levels and maximize glycogen depletion every single time. The proof is really in the pudding. Carol’s effectiveness was independently verified by the American Council on Exercise. gave the Carol bike spin health optimization summit in London this year. And she kicked my ass so much that I had to get one. Check out Carol Carol fit ai.com that’s CAROL fit ai.com if you have limited time and want to kick ass workout, which basically everyone that listens to this show does use the code decoding 150 for $150 discount. Head over to Carol fit AI com to secure yours.

Jean Francois Tremblay 55:37
You can get it that we don’t we cannot make it because it’s too big. It’s a protein. I haven’t looked into it. I’ve been put in touch with the researcher and California I think doing research on it and I’m looking into being included in one of his research groups. So that would be fun. Yeah, but basically being a protein then it’s hard to find except from those very high tech labs that make those and that’s amazing. expensive.

Boomer Anderson 56:15
Yeah, I can imagine. So Melanotan I versus Melanotan II what is the difference per se?

Jean Francois Tremblay 56:24
I’m not sure actually I know there is moral difference differences. I think melana tend to is more targeted, okay. You need less to have the same effect. But I I never stopped looking at Melanotan one that I saw, well, I got everything I need to show I couldn’t answer

Boomer Anderson 56:46
that. And then and then PT 141. The is that the female equivalent?

Jean Francois Tremblay 56:52
No, it’s the equivalent. It works great for men asMelanotan II to so but if you’re dark already You don’t want to get darker than your us PT140 it’s a modified version of Melanotan II to where they were able to take off the tanning effect. Okay,

Boomer Anderson 57:11
interesting. Can we talk now about the growth hormone secreted God families? Okay. So I look at these and correct me if I’m wrong here because, you know, I’m just the end of one guinea pig the morelin family. So Tessa and ipamorelin Yes. So my, my experience with growth hormone comes more from the bodybuilding world and somewhat from the sarens world. What How can we use the morelin family strategically and what kind of benefits can we get? Okay.

Jean Francois Tremblay 57:54
Well, basically they make cues to create your own growth hormone right? So, and I met a few people it told me Yeah, but I get the prescription already of growth hormone. So why should I take that? Well, firstly, it’s a lot cheaper. And two is it’s more natural. So to say it’s your own growth hormone and it comes out and your own natural way, the peak and the way it goes down. So it’s, yes, you force the secretion. But it’s not like a brick falling on you like when you inject GH and bang it sit there and deal with it. So that’s one thing, it’s more natural to it turns out that the actual peptides as an activity T and tissues and dependent from the growth hormone secretion, meaning that even if there was no growth hormone secretion, the peptides because they’re grillin similar, they are graylien receptors and all tissue is muscle bone liver everywhere. So those peptides bind to those receptors and other tissues and have a positive effect. Then you have the secretion of the growth hormone that goes around. So you have this second wave of positive effect from the growth hormone that has its own receptor. And then you have a third wave because to the liver, you have IGF one that is secreted due to the rise and growth hormone. So you have a third waves, IGF one has its own receptors that has positive effect on the tissues. So, Basically if you inject growth hormones, straight up you have two waves of positive effect. If you use a growth hormone secretly dogs, you have three waves you have an extra layer of positive effects that happen. So at this point, the only time I would use I trial growth hormone is if you would want extra physiological level because there’s so much you can secrete this so if you wanted more than I wouldn’t give up I would still take the retirement secrets ago and then add some growth hormone to get extra levels. Okay, but insurance to anti aging and you know a bit of body composition. You will do great with only the girl charm own secrets. You won’t need that all the Growth Hormone itself. So when it’s off, that’s basically the

Boomer Anderson 1:01:04
difference. So the growth hormone is the growth hormone. When I think of people over using growth hormone, I go back to that bodybuilding analogy, right? And so people who just ramp it up, hit the gas pedal, etc. But what we’re doing here is just, if we’re making some sort of dish, if you will, we’re just contributing ingredients to that dish in order to complete the dish. Do I have that

Jean Francois Tremblay 1:01:30
exactly, because what happened is starting around the age of 25, your own secretion of growth hormones start to decrease. So by the age of 50, 60, 70, it’s kind of very low. So as you said there in anti aging purposes or healing you don’t secrete enough So, you know, people take testosterone in their later years as testosterone replacement therapy. So growth hormone should be considered to within the hormonal replacement therapy. And again, those growth hormone secret the guy do the job, because you know your own secretion decreases. But it’s very rare that your ability to secrete a decrease, meaning you take 80 years old, give him a secret to God. And bang is going to start to secrete growth hormone the same as when he was 25. So basically, it’s trying to bring back not taking too much but bring back youthful levels.

Boomer Anderson 1:02:54
So is there any age at which point it’s probably too early to start this like you Should you? Yeah. Yeah. I don’t think a 12 year old anywhere or you know, somebody who’s going into puberty probably shouldn’t be touching this stuff. But

Jean Francois Tremblay 1:03:11
yeah, but no, listen. As a rule, it’s hard to tell basically that you look, you have some blood test done and look at your level and then decide because like woman, some woman, they get menopausal. Early 40s. Other they get menopausal all mid 50s been out there is a range of ages. And the best is just to do a simple blood test. Look at IGF one levels, a couple of other markers, and then decide, okay, that could be a good time to start. But to look at those markers before the age of 30-35, I don’t think the need would be there. Okay.

Boomer Anderson 1:03:59
So Looking at so Tessa and ipamorelin specifically? Well, one thing that we talked about was the ghrelin receptors and how it acts on that, but

Jean Francois Tremblay 1:04:10
well, there is growth hormone releasing hormone and allowing ipamorelin his growth hormone releasing peptides or a grill in there to cause differentiating factor.

Boomer Anderson 1:04:33
Okay. And so how does let’s say you can take either one, how do they act differently is ipamorelin the one that you just walk through in terms of its sequence.

Jean Francois Tremblay 1:04:43
Yeah, that’s why when you take them individually, you get results, because they kind of crossover in their activity, but with a stronger effect in one class and the stronger effect and the other One so the growth hormone GRH is more to send a signal to the pituitary gland to produce to start synthesizing growth hormone and weaker senior signal to secrete it as the growth hormone releasing peptides is stronger on the releasing part and less on the synthesis. So, that’s why tessamorelin you see, you know it’s it’s been very publicized well one pharmaceutical company sells it. So Oh, you know, publicity, big rage about it. You know, it all goes together. It’s not that much better, but it was pushed by the pharmaceutical world, if you have to take a lot of it to see those effects, that’s one milligram or two per day. That’s a lot. And if you take ipamorelin, there are people who have taken that those high dosages up to one or two milligrams, and you have great effects too, but you have to take a lot. But what was found out many back back in the 90s, is that if you use much smaller dosages, but at the same time, that’s one of those cases when you have one plus one, quality, three, four, or even five, because you send both signals at the same time. So you have a huge synthesis and a huge secretion. So if It’s because people they compare tessamorelin with CGC. But it’s a false comparison because it’s different dosages, you know, if if you use one milligram of tessamorelin, well compared to one milligram of CGC 1295 and then see if there is a difference or not. Or you know, but now they compare one milligram of Tessa Margolin with 100 microgram of CGC and 100 micrograms of ipamorelin. So, even if it’s a fact because we combine them those edge wise you know, you’re in the 10 fold difference. So if you cannot really compare, and clinically, I don’t actually most people get sir the combination CGC 1295 ipamorelin in smaller, those are just the high dosages of tessamorelin.

Boomer Anderson 1:08:07
Okay, so just in terms of dosing you need a higher dosage of one milligram for tessamorelin order have

Jean Francois Tremblay 1:08:14
one that’s because again because it’s taken a long so if you want that strong secretion effect you should take more solid it’s gonna kick in more. But if you are to take tessamorelin, I would say take less and take it with ipamorelin. And so yeah would be what it would be last night. I would go I would go to those the same as CGC. But again, if you use same dosages probably you’ll see pretty much the same effect. You know, I don’t know if anybody would try this but that would be Resting, you know, try I want

Okay, well one milligram of tessamorelin for a few weeks, take a break and then try a milligram of CGC 1295 for for a few weeks and see if there is actually a difference or not. So,

Boomer Anderson 1:09:21
okay, we’ve covered tessamorelin, ipamorelin, pretty well now looking at CJC because you just brought it up. Yeah, one of the things I found fascinating about it is you can use it as a topical or I’ve seen it as a traitor. Okay, since you’re laughing, I would like to hear more about.

Jean Francois Tremblay 1:09:41
Well, the first line of defense of the body is the skin and the skin we have protease enzymes that digest proteins including but I So, right off the bat you put a peptide on the skin, some of it will be destroyed before it’s absorbed. Not if the part of what percentage will be absorbed, it depends on its if. If it’s I drew a fog or our general feeling that has to do the size of the peptide, the thickness of the skin. Of course if you apply it within the, you know, the little hole and the full of your arms can is very thin there. It would be but it will never be. Those are solutions. They give for people that for some reason, don’t want our like scared batshit from injection So but now you are you probably you will have some absorption but forget about the hundred percent and you see it usually in like testosterone you have testosterone Korea you get like maybe 5% absorption so that becomes very costly so far that died let’s say you have about the same absorption 510 percent so it’s gonna cost you 10 times more so not saying it’s not working but hey if you can afford it and you know what at all to inject yeah but now they do it.

A lot of people have companies, pharmaceutical and not they always come up with new products like that To be the to make that Okay, we have that nobody else have. And people don’t know much about that. They say, Oh, yeah, must be good. And there is a lot of marketing behind that. But the actual science of skin absorption. It’s not great. Why don’t they make batches of insulin for example? or this or that insulin is a peptide and you know, yeah, that that that would be much more. That would make a lot of sense for a diabetic people. You’re stuck for four or 534 injections per day for the rest of the life. Yeah, let’s make a batch for those people. So you know, they don’t have to worry much about timing and everything, but they don’t because it doesn’t work. So and suddenly you have those people they say, Yeah, okay, doesn’t work for insulin, but it works for a CGC Wow, how not There is always some absorption but it’s very small, very small so and to me it’s not worthwhile to CjC 1295 better injected and sounds like sub Q. Now peptides always

Boomer Anderson 1:13:17
terms of dosages are we talking 100? I think you said micrograms, right?

Jean Francois Tremblay 1:13:22
And microgram. Okay. With those you get the diminished returns. So it seems that the beak effect it’s at around one microgram per kilogram of body. Not saying not if you double that those age, okay, I’ll put it another way. So you have that secretion of growth hormone.If you want to double the secretionroughly.You need to Take about four times the peptide, you understand that’s what I was talking about diminished, there is a point where you have to take a lot more to get a smaller effect. So that’s why usually they recommend when they say 100 microgram, that’s based on the hundred kilo person and it kind of become mainstream. Most people don’t know where it comes from, but it comes from that one microgram per kilogram of body weight. So yeah, you can take more but if you double the dose age, you will get about 25% maybe more, maybe 30% more secretion and if you double that, then another 25 it’s not that receptor are saturated, but they’re getting more clouds. So to say so you get less effect. So the optimal dose age is around that one microgram per kilogram.

Boomer Anderson 1:15:09
One of the I think the last area at least for today I want to touch on are some of these longevity peptides which have come to my awareness recently. Kind of the Fox03 Fox04 or families What are your opinions on these? Because, one it’s very hard to test the success of longevity, right? Yeah. Yeah. And you know, I look at these and say, Hey, fox04, Fox03, that’s, that’s super promising, but what do we know about them?

Jean Francois Tremblay 1:15:44
Okay, well, basically mostly that the one that is being used right now, fox-o-dr4 . It kills senescent cells. So senescence cell basically it’s a cell that is that it’s the end of its life but doesn’t want to die. So it’s not doing anything anymore for the for the body, but it’s still metabolized so excretes inflammatory factors, all kinds of things you don’t want, but it’s not doing nothing positive. So as we grow older, we start to accumulate those senescent cells and they’re just lying there. Just making trouble basically. So that peptide, true the pieces, the three pathways, kills, kills that makes them die so you get rid of them. So the theory is that center sense is the base of it are senesin cells and in mice Works amazing the event like the marker of mice, if you extrapolate to human a treatments therapy on mice brought them human equivalent to 20 years younger not only stop the aging it make them actually younger by 20 years the equivalent you know, they had, they were black mice. So they had gray hair. The hair came back black and all the markers they looked at were improved to more youthful levels. So the effect was amazing. Now from the actual guy, that German guy who worked on those peptides, nine German, the acting, or Holland maybe I’m not sure. problem with that one in particular is that it will kill rough One thing cell for every 10 senesin centrist is gonna kill, so you have to be careful with them. So first, there is not so much used to use it if you are 50 or less because you can start to accumulate or you could do just a little bit. So I’m not sure quite sure how to work with it, I wouldn’t go on the full therapy with it because you went killed too many same cells at once. I would if I started using it, but I’m very careful and what I’m doing is I’ll do maybe three to five shots, spread out on a couple of weeks and then leave it leave it for a couple of months. So you will kill a bunch of senesin cells, you will kill some same cells but then not die. Many because you then go full protocol. So you rebuild those same cells that you kill and you know those organs and everything. And then another small couple of weeks and two months where you rebuild. And maybe you could introduce BPC 157, and the after to help repairing delay damages, you may send a large damages. So maybe that would be a safe approach of using it right now. I know they’re working on the new version. I don’t know what you’re going to call it where now the ratio would be 100 to one. So now that’s more interesting now the release that the sequence so we can make it but it will become available eventually. So it’s very promising but again, they are doing a bunch of research or is a good good Video and interview with the guy who discovered or came up with that molecule and he has very insightful information on it it says because yes in a sense is the root and fox04 works but not at all the aspects of killing senesin cells and in the future probably and there are other labs working on other molecule that work on other aspects of the senescent cells to get rid of them. So probably within a few years, you will have a more complete empty senescence but around maybe three, four or five peptides, you know, working different angles and then you will have them more sound therapy. But we’re going there Yeah, not not saying that you’re not gonna die because Death is actually pulled in our DNA, we’re stuck with that. And that’s why we do all those things, you know, because I have your old body when you’re young is programmed to grow, to reproduce, but at a certain age, and that’s genetically program, then that start to kick in or the dying processes. So the you may train all you want and have the best of diet, the only way to push that away further or, or at least to get a better quality of life is eventually you have to tweak with that biochemistry. And that’s what we do with peptides. So among

Boomer Anderson 1:21:50
others analytics is a fascinating field. And we’ve had Aubrey de Grey on the show as well, who’s who’s doing a lot of interesting research here and they you for sharing this now. Jean Francois Has anybody blown themselves up yet with peptides? Are there any sort of horror stories that we’ve heard come out of the world?

Jean Francois Tremblay 1:22:11
No again to come back dlm the our stories I’ve seen is with autoimmune response to pepti then people that knowing they would get that respond they took a full those and bang you know, they would become like red like a lobsters and things like that. But besides that, no, no nothing so

Boomer Anderson 1:22:37
on the auto immune response is that it hasn’t induced an autoimmune condition. It’s more just that response itself and then it goes away.

Jean Francois Tremblay 1:22:47
Yeah, it goes away. As soon as the peptide the great, but then that can be worked on because they are there is one peptide that modulate the immune response and that’s time as an alpha one. So, usually when you have somebody like that, then you put them exclusively on time as an alpha one or a few weeks to stabilize, so to say the immune system and then they can start a peptide therapy for their condition the immune system have been taken care of. So and then usually you can start that dynamic directly without any problem.

Boomer Anderson 1:23:41
One of the common criticisms on this and I know we’re coming up on time because you’re very generous with this, but one of the common criticisms of peptides is sourcing and how to get all gotta get good source for peptides because You know, there’s been studies out there that just said like, hey, most of this,

Jean Francois Tremblay 1:24:03
they I’m surprised I knew that most of those companies on the internet would get from China. But to such an extent, I’m still surprised. It’s ridiculous. You know, I think in September, I came up with a little video very unprofessional. I have a YouTube channel, it’s can land on YouTube, and the video is there. It’s very unprofessional. But people you know, I have a company we sensitize that died in Montreal. But it’s easy to say, you know, all those people they say now, they show you pictures of huge labs. But with no, well, it seems to get pictures of the Internet of lads. So I’ve turned three years and people Pauline Oh yeah, you make them in Montreal I say Yeah, yes. Okay, I’m gonna make I was in the lab I gave my friend my phone I say let’s make a small video. And then the video I showed I showed pretty much everything you know the reactors were the peptides is sensitize the HPLC and machine to test the little thing we used to put in vials. So to show people Yeah, no, it’s me on the video and yours the lab and we’re, it’s we’re making it right now. So me I expected kind of a response to that from those big players. You know, I won’t name anybody or any company but I say okay, you know, they’ll come up with something and much better, more professional and nobody came out so far. It’s like, Is it because they don’t want to or because they can’t you know, it makes you think They could and they don’t that’s not a good market thing. Yeah. So if they don’t it makes you think that’s because they don’t make them. So they cannot show you to that extent them making them because they don’t. And and the problem getting them from China, Chinese are known to be very, if they can touch you a fast one they will. The worst case I’ve seen is them putting on the market growth hormone and they would release the best growth hormone you could get on the net for about six months. And that’s many years ago and then there is one drug, I don’t know which one that gives you a lot cheaper than growth hormone that gives you that carpal tunnel inflammation as a side effect, so they replace the growth the growth hormone by that dress. So people, they add that effect growth hormone, it’s working, I get carpal tunnel inflammation after a month or two, so must be good. So they started to sell that drug instead of the growth hormone. And people will get that carpal tunnel inflammation. So they say, oh, yeah must be at you know, it’s I get the side effect of good growth arm.

And until somebody one day decided to test and they said well they did that for a long time. And because that’s the thing, people don’t, they don’t have access, they cannot test things, you know, or it’s very expensive. And okay, for example, no work, we found out that we can incentivize it so long. But meanwhile, I wanted some dice. So our dirt from one of those refillable company on the net. And but first thing I did that we tested it, because I was a bit suspicious, I say, No, it’s too cheap to be true. You know, I know I can sell it that cheap. Well, it turns out, it was not the accent. It was a mix of three or four compounds. I don’t know which one that probably would give the same kind of effect. And even though you get that, maybe some other no tropics, much cheaper. But the point is, it wasn’t the hexa but I found out because we have a HPLC and it took five minutes. We tested it and oh, that’s not the accent. But for most most people, they cannot do

Boomer Anderson 1:28:47
that. Yeah, we don’t have HPLC is in our home.

Jean Francois Tremblay 1:28:50
And the Chinese know that. So Oh, did they take advantage of that fact? testing. So john Francis In terms of sports right now, and professional sports, are we able to test for the use of peptides? at all? Yes and no. Yes, because they are detectable in the blood. But again, I mentioned parties we have parties in the blood, so no peptides. Most of them they want class like at most 12 hours and then no blood test on the planet right now will detect. So, if you use a peptide, so what is done right now and the sport word is they take much of your dosages, but more instead of every day, maybe once a week. So they get and it’s a bit like training you know if you give a big, big city feminists know you’re trained for an hour, but you build muscle for a few days after. So the tour is the stimulus is not there anymore but the metabolite chain is. So with a lot of peptides, not well, you see that. So you take a very high dosage, the peptide itself is gone after let’s say 12 hours, but the after effect last for many days, so that’s what they do now. So they would be very unlucky to be tested in that 12 hours frame over a week. Gotcha. So they take that they take that chance, interest that even if they are random testing, so basically that’s how it’s done.

Boomer Anderson 1:30:42
At this what peptides Are you taking right now?

Jean Francois Tremblay 1:30:46
Right now I take CGC 1295 with the ipamorelin, Melanotan II once in a while to keep my For the other effect I’m 56 oh yeah, once in a while maybe one shot of time isn’t better for maybe once every two weeks preventive you know repair little things here and there. And I did not so long ago I didn’t much see for a month every day. I’d love that. Have you done any D plus?

Boomer Anderson 1:31:30
I have I have done more sub q injections not

Jean Francois Tremblay 1:31:35
No. Okay. Do you like it?

Boomer Anderson 1:31:36
Well, I think the IV I didn’t really notice in effect, to be fair.

Jean Francois Tremblay 1:31:41
Okay. me I’ve done in the first start after five days took five days to come again, either very strong effect. But you take mudsy it’s like any the plus on steroids.

Boomer Anderson 1:31:54
And what’s the compound? How do you spell that compound m

Jean Francois Tremblay 1:31:59
M O T S / bar C. Oh awesome. See, it up regulates and is a plus but it’s a mitochondrial peptide. It’s fascinating and basically people want the first first study they were looking at metabolic syndrome you know where you have blood pressure inserted in the resistance and I cholesterol So, and that molecule works on all of that brings it down. But there is a bunch of we could do another podcast when they all know we are we are because this is fascinating, but must see, listen, you feel so good on that, you know, energy wise it could be psychologically addictive. But you really rev up the mitochondria. So I wouldn’t do it all the time. But you know also, that’s why Baby weeks again that’s pretty much it for now we’re synthesizing new peptides. I will try them out. Like for example, okay, you are asking a man I’m gonna attempt to in higher dosages is very good for it’s very intense I matter. But the problem is if you use it for that, then you will become too ridiculously dark. Yeah. So but they found out that it’s the true part of fraction of Melanotan two, three amino acids that have that intense amatory effect. So now we’re just finishing a batch we synthesize it, so you get only the inflammatory effect. So there is a few new ones that we’re working on. We could quickly Another podcast from those Russian by your regulators. They’re like a beat. I don’t want all there is about 25 of them. It’s it’s amazing guys. I told you, you know when we got in touch with one but can we only scratching the swirls? I’m going to

Boomer Anderson 1:34:15
evolve that I want to have you back on so we’re going to scratch the surface some more, because I think this could be it. No, no no ongoing conversation. Jean Francois, just cognizant of your time, I want to move over into just the final six rapid fire questions if it’s okay, what’s your What is your favorite piece of technology that you bought in the past year?

Jean Francois Tremblay 1:34:41
The oaring I like and, oh, just a little parenthesis. In a way why it’s good to speak many languages. They did that study at the end. One of them rebuildable ospital and Paris in their seed clinic they tested like 15 sleep monitors or tracking devices. And to that they found to be actually correct and precise. Where the overing and and the Fitbit in the Fitbit,

Boomer Anderson 1:35:25
really

Jean Francois Tremblay 1:35:26
that wasn’t Yeah, they found you know, because they would compare they would have people in the sleep clinic you know, with all the thing on the electrodes and everything and they compare the results from the monitor and their results. And those were the two outstanding, all the other ones. Now. Again, I’ll find that I don’t know if they published it, but at least the article. It comes from the French science and school get you know, bits like Scientific American but French I’ll send it to you so those were the two outstanding devices so I was that because my wife she used the Fitbit and I have the URL but I don’t know which other one did test it so not to put down any other ones because I don’t know which one they are. So that’s one I like I got that the Carol by Yeah, you and

Boomer Anderson 1:36:23
I both like the Carol.

Jean Francois Tremblay 1:36:25
I like it because I’m lazy but you know that’s why do you go into again biohacking and all those things basically, it’s because really, no, no, I’m not ashamed to say it. That’s the base of any invention that that’s why society that’s why most inventions are made by men. Women are not lazy so they’re not so creative and finding things to make things easier. You know, again, I don’t want to get into Political, we don’t have to call it to be politically incorrect. But you know, historically that’s pretty much it. So Well, yeah. So the Carroll bike I love it for that, you know, nine minutes at night it does work you know, you see you feel it. Absolutely. So I like that and I’ve got but that within the year that thing from Scandinavia, you know the what’s the word you put in your hears your phones, but it’s with light.

Boomer Anderson 1:37:35
The human charger?

Jean Francois Tremblay 1:37:37
Yeah, human charger. I’ve used it many times, but I’m not very sensitive to that. So I cannot tell if it works or not. But I’m using it. You know, I trust the science behind it. So those would be the tree not looking into it. Next. Tuesday, I’m visiting a place here in Montreal where the firebreak hyperbaric chamber. So I want I’ve read amazingly and got feedbacks of people on on very specific therapies like very serious case, like Ms and all that. And they get much better results when they do their peptide injections and right, right after they go into the hyperbaric chamber. So you have a combined effect that seems to be amazing.

Boomer Anderson 1:38:30
After this, we’re going to talk because one of my mentors who’s been on the podcast before is very big and hyperbaric. And I think you guys would have a very good conversation. Now Jean Francois, how do you unwind?

Jean Francois Tremblay 1:38:49
Oh, by you know, when I The thing I like to do the most and a lot of people That it’s doing nothing.

You know for not like all day long I couldn’t but that’s how I on the wind. I will take maybe half an hour, just sit back, do nothing. Just day thing. I don’t know, a lot of ideas come out during those time, but that’s all on the line. I just stopped everything. Don’t sleep, just lay back and do nothing. I really enjoy doing nothing. It’s the power of silence, right?

Boomer Anderson 1:39:37
favorite holiday or vacation destination and I am very curious about this one because you’ve lived all over the world.

Jean Francois Tremblay 1:39:44
Yeah, it’s difficult because many places I haven’t seen but and it’s biased because a lot of places I live there so I’ve like Max sico. I lived in Mexico City. For like 10 years, not the best place to live because of contamination and all that, but that I love. I love that then it was in the time where it wasn’t so terrible and so you know, I never had any problem but I actually the place I love to live the most is at one point I bought a house in Mexicali. two hour from Tijuana I was 15 minutes from the border. So it was I had the best of Mexico and the best of the US because anytime I was in the US maybe three four times a week crossing two hours from San Diego three hours from LA seven hours from Las Vegas. So you know I was close to all those focus points so to say with and you know, I would cross and then the town the other side Calexico, the other Walmarts 25 I was right there at the border. So I had the best of both. And I really and the climate that’s very hot in the summer, it’s some days it’s up to 50 degrees. But I like that think and they attracted by opposite. Yeah. So it’s their thing. It’s next to Death Valley. But I love that that’s, that’s one place.

I wouldn’t mind living it, you have to check that out.

Boomer Anderson 1:41:26
What is your top trick for enhancing your productivity?

Jean Francois Tremblay 1:41:33
So looking, make this list of things, because I make them in my head, but then I forget. So I’ve noticed when I make lists, not not to do because some people they say no, it’s not good to do lists because you end up doing everything. That’s true. But at least you do something. So I like to make a list. most productive when I do that, let’s say I have those steps. things to do. And I do I like Canada Day with priorities. But then what I didn’t do I put it on the next day. Plus other things and you know, and basically, if I want to be productive to do that, that’s how I get really productive. What’s your favorite book?

Boomer Anderson 1:42:22
What book has significantly impacted your life and how you show up to perform in

Jean Francois Tremblay 1:42:29
a life extension that was published in 1982. I was only 19. And I was worried about that. But Dirk it’s a big book. And what was known at the time, was, you know, like for growth, our monster Christian, they would throw them the ornithine and are getting, you know, bah, bah, bah things like that. Very, but basically by then what I took out of that as an anti aging and they stated it somewhere when you grow older and that’s all from that book what you are you have to control two things. Your glass the same Yeah, your blood glucose or glucose, you know you can extend but the Samia and inflammation those are two things that you need to keep in check if you want to live long and and they were right. Basically everything you see today’s all around. Amazing. Now their approach to it was you know, David’s Okay, take aspirin for inflammation, things like that. Well, okay, but a lot of things are still good and look amazing.

Boomer Anderson 1:43:52
Sean Francois, where can people find out more about you? Well,

Jean Francois Tremblay 1:44:01
The best I think, would be I have a Facebook page for canlab. I hate to write so I don’t write much there but sometimes, oh, you know where there is a Facebook group. It’s not my group. It’s a woman in Toronto. Natalie was it and about twice a month I do small podcast where not like this one, but where, again, it came out from the fact that I don’t like to write. So I was getting tired of answering the same question over and over, you know, in the group. So what we would, what we do now is we kind of gather she gathers those questions that repeat themselves and or those doubts and then twice a month about a maybe a half hour to an hour. just answering those questions and for other people in the group. So the group it’s called biohacking.

Boomer Anderson 1:45:09
I think it’s bio hacking superhuman something. That’s it. That’s a link to in the

Jean Francois Tremblay 1:45:14
show. I totally I’m gonna make a new one tonight. So, you know, if people want to join that group, then it’s a good place, those groups that tight groups and all that I get a lot of, I learned from that, again, because you know, people, they ask questions about things that are happening, and sometimes it makes me it forces me to look up and I don’t know the answer. And I’m learning from that. And it’s very interesting that you can exchange or ask

Boomer Anderson 1:45:44
questions and, and then your company’s called chem lab, is that right?

Jean Francois Tremblay 1:45:49
Can lab know s ch en la B? So cam lab as a Facebook page where sometimes I write little things and bye For information yeah that group is pretty good

Boomer Anderson 1:46:03
actually it’s and if somebody wanted to speak to you directly I think cam I pas consultation

Jean Francois Tremblay 1:46:10
Yeah Can lab.net and then I’ll for online like Skype consults and all that there are two kinds there is the personal one. And the professional sometimes people don’t understand the professional one is much more expensive but that’s for the medical field because I do consults with doctors. So of course they asked for practical but not for for themselves, but for their clients. So you know, they’re going to make a bunch of money out of it. Plus for them it’s tax deductible. So I charge the money. But there is that personal one. That’s one to one for you know, we discuss

Boomer Anderson 1:46:59
awesome Jean Francois, thank you for taking the time today. This has been absolutely amazing. And I’m going to go ahead and I’m going to bring you back for around two because this is like we’re only scratching surfaces here.

Jean Francois Tremblay 1:47:12
No problem but I would

Boomer Anderson 1:47:14
love to all the superhumans listening out there. This is Boomer and john Francois signing off. Have an epic day. Like I said at the beginning superhumans, we are just scratching the surface here. If you want us to go deeper, send me an email podcast at decoding superhuman calm. I would love to have john friend saw come back on for round two. But we want the demand to be there. So please email me at podcast at decoding superhuman calm. Let me know what you think of the episode. Let me know what you think about peptides in general and any questions that you have, and we’ll get him back on for that round too. If you enjoyed this episode, please share it on all the social medias that could be Tick Tock. If you’re watching One of those people, or it could be something like LinkedIn. Let me know what you think. Please comment please like please share. And again the show notes for this one are decoding superhuman comm slash peptides. Super humans have an epic day.

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